Methodology

^: co-first author

  • Hu H, Wang X, Feng S, Xu Z, Liu J, O’Hare E, Chen Y, Yue M, Zeng L, Rong Z, Chen T, Billiar T, Ding Y, Huang H, Duerr R, Chen W. A unified model-based framework for doublet or multiplet detection in single-cell multiomics data. Nature Communications. 15, 5562 (2024). https://doi.org/10.1038/s41467-024-49448-x
    (Selected as a featured article in “Biotechnology and methods” section)

  • Wang X, Xu Z, Hu H, Zhou X, Zhang Y, Lafyatis R, Chen K, Huang H, Ding Y, Duerr R, Chen W. SECANT: a biology-guided semi-supervised method for clustering, classification, and annotation of single-cell multi-omics. PNAS Nexus. 2022 Sep; 1(4): pgab165 https://doi.org/10.1093/pnasnexus/pgac165

  • Chen Y, Wu X, Ni K, Hu H, Yue M, Chen W, Huang H. Robust and Accurate Doublet Detection of Single-Cell Sequencing Data via Maximizing Area Under Precision-Recall Curve. bioRxiv; doi: https://doi.org/10.1101/2023.10.30.564840

  • Rong Z^, Hu H^, Duan J, Liu T, Feng S, Zhao C, Duerr, R, Zhou X, Chen W. scDitu: a cluster-free method for identifying isoform-level differential transcript usage in sparse single-cell long-read sequencing data. Under review at RECOMB conference

  • Yue M, Cai M, Zhao C, Tao S, Liu J, Hu H, Chen Y, Celedon J, Wang J, Huang H, Chen W. Multi-Omics intermediate Fusion Enable Digital White Blood Cells Count Prediction. Submitted to Genome Medicine

  • Yuan R, Rong Z, Hu H, Liu T, Tao S, Chen W. Harmony-Based Data Integration for Distributed Single-Cell Multi-Omics Data. Submitted to Nature Communications

Collaboration

  • Xu Z, Tao S, Feng S, Wang T, Hu H, O’Hare E, Chen W, Duerr R. Dissecting PGE2-Driven inhibition of T Cell Activation Using Single-Cell Multi-Omic and Inflammatory Bowel Disease Genetic Association Analysis. Nature Genetics (In revision)

Book Chapter

  • Wang X, Hu H, Chen W. Model-based Clustering of Single-cell Data. Book Chapter In: Handbook of Statistical Bioinformatics (2nd Edition) 2022 (pp. 85-108). Chapman & Hall/CRC.